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Tissue Microarrays
Tissue MicroArrays are a method of re-locating tissue from conventional histologic paraffin blocks or frozen tissue samples. There are numerous advantages to this technology including: amplification of a scarce resource, experimental uniformity, decreased assay volume, and it does not destroy the original block for diagnosis. Tissue MicroArrays are amenable to a wide range of techniques including histochemical stains, immunologic stains with either chromogenic or fluorescent visualization, in situ hybridization (including both mRNA ISH and FISH), and even tissue micro-dissection techniques.  Our proprietary Tissue MicroArray transfer technology assures a >95% transfer efficiency.

Key Features:
Study multiple samples of a tissue/tumor type on a single slide.
Multiple tissue types (tumor and normal) on a single slide.
Conserve tissue and reagents      
Interpretation services
Large Format, Low & High Density Arrays
Regulatory & FDA Arrays
Custom Arrays
Clinical Information
Many disease formats already prepared with match normal samples included.

Tissue MicroArray Formats now available:
FFPE - high and low density
Frozen
Large Format                                                                                    
Starter TMA sets also available



Immunohisotchemistry (ICH) profiling and assay development are our specialty. Request commercially available or novel antibodies on meticulously designed Tissue Microarrays for a complete tissue synopsis. Proprietary Tissue Microarray Technology enhances custom array design.

Custom Tissue MicroArrays:
Cytomyx has developed superior tissue MicroArray technology which enables our consistent imprinting of tissue specimens on microscope slides. Our proprietary Tissue MicroArray transfer technology assures a >95% transfer efficiency. Large format, low and high density arrays are available in broad surveys of specific diseases or may be customized by request. 

Low Density Head & Neck Cancer SurveyArray: Over 60 histologically-defined carcinomas, Pathologist-reviewed; includes Mouth, Tongue, Parotid, Salivary, Palate, Larynx, Pharynx, and lymph nodes of the Head and Neck, with matched adjacent normals.

Array Formats:
FFPE - high and low density

Low Density Pancreatic Cancer Array: Over 60 histologically defined carcinomas. Pathologist-reviewed; representing all stages and grades. pancreatitis, with matched adjacent normals. 

High Density Breast Cancer Survey: Over 200 histolocially-defined carcinomas by Pathologist review, representing virtually all stages of breast cancer , DCIS thru Stage IV, including matched normals, benign diseases and clinically-defined normals.

Frozen Large Format


             
Frozen Large Format Colon Cancer Array: Proprietary frozen tissue microarray technology allows review of unfixed samples. Evaluate tissues in their original heterogeneous state. Customize an array of individual elements that measure 3.0-5.0mm in diameter.

Large Format  


  
Large Format Normal Array: Evaluate tissues in their original heterogeneous state. Each array consists of 40 individual elements that measure 3.0-5.0mm in diameter.


    
Large Format Rat Array: Includes normal organ systems such as heart, lung, liver, kidney, brain, colon, spleen, and pancreas.


                  
Large Format Spinal Cord Array- Ventral Horn: Formalin fixed paraffin embedded arrays for specific tissue types.

Fresh or Fixed Tissue: Profiling may be conducted on either fixed or unfixed tissue samples. Our proprietary Frozen Preparation Technique enhances section quality and staining performance. Unfixed and fixed frozen methodologies are employed to demonstrate structures that routine processing methods may hinder.

Data Interpretation: Scoring is provided by an Anatomic Pathologist.  Complete Pathology data is provided on the source tissue samples for accurate analyses of cell-specific histopathology including relevant molecular marker data.

A final report is generated containing pathology data and technical methods for publication and quality assurance purposes.

Clinical Information: Clinical data is provided including: grade and stage of disease, medication history, outcome and follow-up data.

Abbreviated Sample Table: